Interaction of Ross River Virus with the Complement System
نویسندگان
چکیده
منابع مشابه
Interaction of Ross River virus with the complement system.
In the absence of virus-specific antibody, Ross River virus failed to activate either the classical or alternative complement pathways. Instead, it inhibited the cleavage of C3 via both pathways. The virus did not appear to act by disrupting C3bBb complexes or by preventing cleavage of factor B by factor D. Instead Ross River virus was found to interfere with the actual cleavage of C3 by activa...
متن کاملComplement receptor 3 promotes severe ross river virus-induced disease.
Alphaviruses such as Ross River virus (RRV) and chikungunya virus are mosquito-transmitted viruses that cause explosive epidemics of debilitating arthritis and myositis affecting millions of humans worldwide. Previous studies using a mouse model of RRV-induced disease demonstrated that viral infection results in a severe inflammatory arthritis and myositis and that complement component 3 (C3) c...
متن کاملRoss River virus.
BACKGROUND Ross River virus is Australia's most common and widespread arbovirus. It causes epidemic polyarthritis and is associated with significant morbidity and cost to society. OBJECTIVE This article aims to increase clinicians' awareness of the epidemiological and clinical features of Ross River virus and provide information regarding prevention, diagnosis and management. DISCUSSION Ros...
متن کاملMolecular genetic study of the interaction of Sindbis virus E2 with Ross River virus E1 for virus budding.
Glycoprotein PE2 of Sindbis virus will form a heterodimer with glycoprotein E1 of Ross River virus that is cleaved to an E2/E1 heterodimer and transported to the cell plasma membrane, but this chimeric heterodimer fails to interact with Sindbis virus nucleocapsids, and very little budding to produce mature virus occurs upon infection with chimeric viruses. We have isolated in both Sindbis virus...
متن کاملClimate variability and Ross River virus transmission.
OBJECTIVES (1) To examine the feasibility to link climate data with monthly incidence of Ross River virus (RRv). (2) To assess the impact of climate variability on the RRv transmission. DESIGN An ecological time series analysis was performed on the data collected between 1985 to 1996 in Queensland, Australia. METHODS Information on the notified RRv cases was obtained from the Queensland Dep...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1985
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-66-1-121